(건강) 정신분열증을 예방하는 면역성 단서

출처: http://www.bbc.com/news/health-34540363

5 hours ago: October 16, 2015

Immune clue to preventing schizophrenia 정신분열증을 예방할 수 있는 면역성 단서

By James GallagherHealth editor, BBC News website

Brain scans discovered higher activity levels in part of the brain's immune system in schizophrenia patients than in healthy volunteers 두뇌 스캔사진은 정신분열증 환자들의 뇌 속 면역체계의 일부에서 건강한 사람들보다 더 높은 레벨의 활동성을 보였다.

It may be possible to prevent schizophrenia by calming the brain's immune system, say scientists. 과학자들은 두뇌의 면역체계를 안정시킴으로써 정신분열증을 예방할 수도 있다고 말한다.

Brain scans found an overactive immune system in patients as well as in those at high risk of schizophrenia. 두뇌 스캔사진은 정신분열증 환자들과 정신분열증의 높은 위험을 갖고 있는 사람들 안에서 지나치게 활동적인 면역체계를 보여주었다.

The UK Medical Research Council team wants to test anti-inflammatory drugs to treat or even prevent the disease. 영국의학연구소 연구팀은 정신분열증을 치료하거나 예방하기 위해 소염(항염)제를 테스트하고 싶어 한다.

Other experts in the field said the study, in the American Journal of Psychiatry, was "important" and furthered understanding of the illness. 미국정신의학회지에서 이 분야의 다른 전문가들은 이번 연구는 중요한 연구였으며 정신분열증의 이해에 진일보했다고 말했다.

There has been mounting evidence that the immune system and inflammation play a key role in schizophrenia and other psychiatric conditions.

The researchers analysed microglia, which are like the brain's own gardeners weeding out infection but also "pruning" unwanted connections between brain cells.

A chemical dye which sticks to microglia was injected into 56 people to record their microglia activity.

The highest level was found in patients with the condition, but those deemed at high risk of developing schizophrenia also showed heightened activity levels.

Brain scans show higher levels of microglia activity (orange) in people with schizophrenia

Dr Oliver Howes, the head of the psychiatric imaging group at the MRC Clinical Sciences Centre, told the BBC News website: "This is a real step forward in understanding.

"For the first time we have evidence that there is over-activity even before full onset of the illness.

"If we could reduce activity [before full-blown illness] then we might be able to prevent the illness - that needs to be tested, but is one key implication [of the research]."

He thinks the microglia become like a gardener too keen with the shears and sever the wrong connections in the brain leaving it wired incorrectly.

"You can see how that would lead to patients making unusual connections between what is happening around them or mistaking thoughts as voices outside their head and causing the symptoms we see in the illness," Dr Howes added.

Treatments

Some small trials have suggested that anti-inflammatory drugs may help patients when they have been given alongside traditional medication.

However, further studies are now needed including on anti-inflammatory drugs that target only the microglia rather than those, such as Ibuprofen, that have a wider effect on the body.

Dr Howes advised patients not to self-prescribe the drugs and added that any decisions about medication should be made with a doctor.

It is not yet clear why some people have overly active microglia.

Analysis of patients' DNA - their blueprint of life - has implicated genes that control the immune system.

It suggests some patients are predisposed to having a more sensitive immune system, but events later in life such as times of high stress have also been implicated.

The head of psychiatry at the University of Edinburgh, Prof Stephen Lawrie, commented: "This is an important paper, which both confirms and extends previous findings, in a carefully controlled and state-of the-art study."

He said the findings "suggests the possible amelioration or even prevention of one of the worst illnesses affecting mankind" through drugs to tame the immune system in the brain.